This is a randomized controlled trial that took place in a private chiropractic practice and the National Health Service's health visitor nurses in a suburb of Copenhagen, Denmark. One group of infants received spinal care for 2 weeks, the other was treated with the drug dimethicone for 2 weeks. Changes in daily hours of crying were recorded in a colic diary.
From the abstract: By trial days 4 to 7, hours of crying were reduced by 1 hour in the dimethicone groups compared with 2.4 hours in the manipulation group (P = 04). On days 8 through 11, crying was reduced by 1 hour for the dimethicone group, whereas crying in the manipulation group was reduced by 2.7 hours (P=.004). From trial day 5 onward the manipulation group did significantly better that (sic) the dimethicone group. Conclusion: Spinal manipulation is effective in relieving infantile colic.
Wiberg JMM, Nordsteen J, Nilsson N J Manipulative Physiol Ther. 1999 (Oct);22 (8): 517-522