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Vitamin K at Birth: To Inject or Not

Written by Linda Folden Palmer, D.C.   
Friday, 27 June 2008 11:17
Article Index
Vitamin K at Birth: To Inject or Not
The Numbers
Editor's Note
All Pages

Newborn infants routinely receive an injection of vitamin K after birth in order to prevent (or slow) a rare problem of bleeding into the brain weeks after birth. Vitamin K promotes blood clotting. The fetus has low levels of vitamin K as well as other factors needed in clotting. The body maintains these levels very precisely.1 Supplementation of vitamin K to the pregnant mother does not change the K status of the fetus, confirming the importance of its specific levels.

Toward the end of gestation, the fetus begins developing some of the other clotting factors, developing two key factors just before term birth.2 It has recently been shown that this tight regulation of vitamin K levels helps control the rate of rapid cell division during fetal development. Apparently, high levels of vitamin K can allow cell division to get out of hand, leading to cancer.

What's the Concern?

The problem of bleeding into the brain occurs mainly from 3 to 7 weeks after birth in just over 5 out of 100,000 births (without vitamin K injections); 90% of those cases are breastfed infants,3 because formulas are supplemented with unnaturally high levels of vitamin K. Forty percent of these infants suffer permanent brain damage or death.

The cause of this bleeding trauma is generally liver disease that has not been detected until the bleeding occurs. Several liver problems can reduce the liver's ability to make blood-clotting factors out of vitamin K; therefore extra K helps this situation. Infants exposed to drugs or alcohol through any means are especially at risk, and those from mothers on anti-epileptic medications are at very high risk and need special attention.

Such complications reduce the effectiveness of vitamin K, and in these cases, a higher level of available K could prevent the tragic intracranial bleeding. This rare bleeding disorder has been found to be highly preventable by a large-dose injection of vitamin K at birth.

The downside of this practice however is an 80% increased risk of developing childhood leukemia. While a few studies have refuted this suggestion, several tightly controlled studies have shown this correlation to be most likely.4,5 Apparently the cell division that continues to be quite rapid after birth continues to depend on precise amounts of vitamin K to proceed at the

proper rate. Introduction of levels that are 20,000 times the newborn level, the amount usually injected, can have devastating consequences.

The Newborn's Diet

Nursing raises the infant's vitamin K levels very gradually after birth so that no disregulation occurs that would encourage leukemia development. Additionally, the clotting system of the healthy newborn is well planned, and healthy breastfed infants do not suffer bleeding complications, even without any supplementation.6

While breastfed infants demonstrate lower blood levels of vitamin K than the "recommended" amount, they show no signs of vitamin K deficiency (leading one to wonder where the "recommended" level for infants came from). But with vitamin K injections at birth, harmful consequences of some rare disorders can be averted.

Infant formulas are supplemented with high levels of vitamin K, generally sufficient to prevent intracranial bleeding in the case of a liver disorder and in some other rare bleeding disorders. Although formula feeding is seen to increase overall childhood cancer rates by 80%, this is likely not related to the added vitamin K.


The Numbers

Extracting data from available literature reveals that there are 1.5 extra cases of leukemia per 100,000 children due to vitamin K injections, and 1.8 more permanent injuries or deaths per 100,000 due to brain bleeding without injections. Adding the risk of infection or damage from the injections, including a local skin disease called "scleroderma" that is seen rarely with K injections,7 and even adding the possibility of healthy survival from leukemia, the scales remain tipped toward breastfed infants receiving a prophylactic vitamin K supplementation. However, there are better options than the .5 or 1 milligram injections typically given to newborns.

A Better Solution

The breastfed infant can be supplemented with several low oral doses (possibly 200 micrograms per week for 5 weeks, totaling 1 milligram, even more gradual introduction may be better). Alternatively, the nursing mother can take vitamin K supplements daily or twice weekly for 10 weeks. Supplementation of the pregnant mother does not alter fetal levels but supplementation of the nursing mother does increase breastmilk and infant levels.

Either of these provides a much safer rate of vitamin K supplementation. Maternal supplementation of 2.5 mg per day, recommended by one author, provides a higher level of vitamin K through breast milk than does formula,9 and may be much more than necessary.

Formula provides 10 times the U.S. recommended daily allowance," and this RDA is about 2 times the level in unsupplemented human milk. One milligram per day for 10 weeks for mother provides a cumulative extra 1 milligram to her infant over the important period and seems reasonable. Neither mother nor infant require supplementation if the infant is injected at birth.10

The Bottom Line

There is no overwhelming reason to discontinue this routine prophylactic injection for breastfed infants. Providing information about alternatives to allow informed parents to refuse would be reasonable. These parents may then decide to provide some gradual supplementation, or, for an entirely healthy term infant, they may simply provide diligent watchfulness for any signs of jaundice (yellowing of eyes or skin) or easy bleeding.

There appears to be no harm in supplementing this vitamin in a gradual manner however. Currently, injections are provided to infants intended for formula feeding as well, although there appears to be no need as formula provides good gradual supplementation. Discontinuing routine injections for this group alone could reduce cases of leukemia.

One more curious look at childhood leukemia is the finding that when any nation lowers its rate of infant deaths, their rate of childhood leukemia increases.11 Vitamin K injections may be responsible for some part of this number, but other factors are surely involved, about which we can only speculate.

References:

1. L.G. Israels et al., "The riddle of vitamin K1 deficit in the newborn," Semin Perinatol 21, no. 1 (Feb 1997): 90-6.

2. P. Reverdiau-Moalic et al., "Evolution of blood coagulation activators and inhibitors in the healthy human fetus," Blood (France) 88, no. 3 (Aug 1996): 900-6.

3. A.H. Sutor et al., "Late form of vitamin K deficiency bleeding in Germany," Klin Padiatr (Germany) 207, no. 3 (May-Jun 1995): 89-97.

4. L. Parker et al., "Neonatal vitamin K administration and childhood cancer in the north of England: retrospective case-control study," BMJ (England) 316, no. 7126 (Jan 1998): 189-93.

5. S.J. Passmore et al., "Case-control studies of relation between childhood cancer and neonatal vitamin K administration," BMJ (England) 316, no. 7126 (Jan 1998): 178-84.

6. E. Roman et al., "Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies," Br J Cancer (England) 86, no. 1 (Jan 2002): 63-9.

7. M. Andrew, "The relevance of developmental hemostasis to hemorrhagic disorders of newborns," Semin Perinatol 21, no. 1 (Feb 1997): 70-85.

8. E. Bourrat et al., "[Scleroderma-like patch on the thigh in infants after vitamin K injection at birth: six observations]," Ann Dermatol Venereol (France) 123, no. 10 (1996): 634-8.

9. A.H. Sutor, "Vitamin K deficiency bleeding in infants and children," Semin Thromb Hemost (Germany) 21, no. 3 (1995): 317-29.

10. S. Bolisetty, "Vitamin K in preterm breast milk with maternal supplementation," Acta Paediatr (Australia) 87, no. 9 (Sep 1998): 960-2.

11. K. Hogenbirk et al., "The effect of formula versus breast feeding and exogenous vitamin K1 supplementation on circulating levels of vitamin K1 and vitamin K-dependent clotting factors in newborns," Eur J Pediatr 152, no. 1 (Jan 1993): 72-4.

12. A. Stewart, "Etiology of childhood leukemia: a possible alternative to the Greaves hypothesis," Leuk Res (England) 14, nos. 11-12 (1990): 937-9.


Editor's Note:

Vitamin K Supplementation

Here is the website where you can order Herbal Vita K drops that the mothers can take in advance of delivery and also give to babies at birth, at 2 weeks, at 4 weeks and finally at 8 weeks. You can get lots of Vita K through your foods as well such as alfalfa which will cross the placenta. www.BirthWithLove.com

You can get a recommended Vitamin K here: www.mercola.com/forms/vitamin_k2.htm

Dr. Palmer's informative, well referenced book:, “Baby Matters, What Your Doctor May Not Tell You About Caring for Your Baby” can be bought through the ICPA.

She can be reached at: www.babyreference.com.

Linda Folden PalmerAbout the Author:

Science is Dr. Palmer's first love and continuing inspiration. Her undergraduate degree from the University of Illinois was in chemistry with a minor in biology. While attending the National College of Chiropractic, Palmer received a Bachelor of Science in human biology as she received her Doctor of Chiropractic.

Prior the birth of her son, Dr. Palmer ran a successful chiropractic practice for eleven years, focusing on nutrition and women's health issues. Her practice emphasized diagnosis, research, and patient education.

With the birth of Dr. Palmer's son in 1995, she was confronted with his severe health complications and astounded by the extreme lack of accurate or helpful information from doctors or books. Her usual passion for research turned toward infant health and parenting. Her extensive reviews of science and medical research revealed huge conflicts between what is found scientifically and what is standard protocol in pediatric offices. Her research in this area led to writing Baby Matters.

Dr. Palmer has led attachment parenting support groups for five years, also coordinating the various groups throughout San Diego County. She has also served as an instructor in anatomy and physiology and a research associate for drugless cancer therapy research. She currently spends her time consulting in infant nutrition and attachment parenting, writing parenting articles and books, speaking to family and professional audiences, and being a wife and mother.

Website: www.babyreference.com