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Home Wellness Research Ear Infections (Otitis Media) Placebo Fares as Well as Amoxicillin

Placebo Fares as Well as Amoxicillin

Thursday, 30 October 2008 15:38

While once-a-day dosing was equivalent to twice-a-day dosing for amoxicillin prophylaxis, there was no benefit of amoxicillin prophylaxis compared with a placebo control in preventing new acute otitis media episodes. Because of the potential of excessive antibiotic use to promote the acquisition of resistant pneumococci and the lack of effectiveness in this trial, routine use of amoxicillin prophylaxis should be discouraged.

Roark R; Berman S   Continuous twice daily or once daily amoxicillin prophylaxis compared with placebo for children with recurrent acute otitis media   Pediatr Infect Dis J. 1997 (Apr);   16 (4):   376-381