The immune and endocrine systems are integrated through mutual communication mediated by endogenous mediators such as cytokines and neuroendocrine peptides. Scientific evidence also shows that activation of the autonomic nervous system may lead to alteration in various physiological responses including the immune and inflammatory responses.
Published evidence in the chiropractic literature suggests that spinal manipulative treatment (SMT) may affect the immune system. In the present study, the effect(s) of a single SMT on various aspects of the immune response is being investigated. To: 1) determine whether a single chiropractic treatment induces alterations in the T-cell-mediated humoral (B cell) response, 2) establish if spinal manipulation affects the production of soluble mediators (cytokines) of the immune and inflammatory responses.